What size cooler do I need for two people on a three-day trip?

A 50-quart cooler is the baseline for two people on a three-day trip. Scale using roughly 20 quarts per person per day, but half of that is ice. For a weekend, go with 48-60 quarts for two people. For a week, you need 100+ quarts or two coolers—one for food, one for drinks.