Can thick mousepads cause wrist fatigue?

Yes, thick mousepads (like 4mm foam) can lift your wrist into an extended angle, putting pressure on the median nerve and carpal tunnel during long gaming sessions. Thin pads (2mm) keep your wrist closer to neutral, which is generally better. If you feel tingling or numbness, try a thinner pad or a wrist rest that doesn’t push your wrist up.