Are there any compatibility issues between 32GB RAM and a Ryzen 5 5600X?

No, there are no known compatibility issues — it’s a common, well-tested combination. The Ryzen 5 5600X supports up to 128GB of DDR4, and 32GB kits (2x16GB) are the sweet spot for gaming and productivity. Just make sure you’re buying a two-stick kit at 3200 or 3600 MHz with a B550 or X570 board.