3 Things to Know About Running 4 Sticks of RAM on a B450 Board

3600MHz is unlikely to be stable Most B450 boards use a daisy-chain topology that works best with two sticks. Adding four dual-rank 16GB sticks strains the memory controller, and you will probably need to drop to 3200MHz or lower to avoid crashes.

2×32GB is a smarter choice Two dual-rank sticks are much easier on the memory controller and can reliably hit 3600MHz. If you need 64GB, buy a 2×32GB kit instead of four 16GB sticks.

XMP will probably fail with four sticks Do not expect plug-and-play performance. If you already have four sticks, be prepared to manually tune voltages and timings. Random boot loops are common.