3 Reasons Two Sticks of RAM Is the Best Setup

Two sticks give you full dual-channel performance Running 2x8GB in a two-slot motherboard performs identically to 4x4GB in a four-slot board. There is no performance difference.

Two sticks are easier on the memory controller This is especially true on Ryzen builds. Two sticks also leave more room for airflow around the CPU cooler.

The only downside is no upgrade path without replacing both sticks If 16GB is enough for you now, that is a problem for later. You can always sell the pair and buy a 2x16GB kit.